DOCUMENTED BY BATCHIdentity (HPLC)
High-performance liquid chromatography records the compound’s retention profile against a reference.
Research peptide
MOTS-C
Lyophilized powder, catalogued by compound identity and backed by a certificate of analysis for its production batch.
For laboratory research only. Not for human or veterinary use.
Indicative · checkout opens at launch
Research use only
≥99% purity*
Batch tested
$120.00In stock
Size
10 mg
Buying option
Buy now · $120.00100 in stock
Sealed, labelled vials · US delivery
| Quantity | 5–9 | 10+ |
|---|---|---|
| Discount | 10% | 15% |
| Price | $108.00 | $102.00 |
Indicative volume pricing, confirmed at launch.
View specifications Batch documentation Certificate of analysis
- Third-party tested
- Secure packaging
- Supplied for laboratory research
- Identity by HPLC & LC-MS Compound identity documented per batch.
- Batch-specific COA A certificate of analysis per batch.
- Secure packaging Sealed, labelled research vials.
- Third-party tested Independent testing per batch.
Documented by batch
Every batch is catalogued, tested and recorded.
Overview
MOTS-c Research Peptide
Premium research grade MOTS-c for scientific and laboratory research. MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a synthetic 16-amino acid peptide derived from the mitochondrial genome and represents one of the first mitochondrial-derived peptides to be characterised in detail. Unlike most signalling peptides encoded by nuclear DNA, MOTS-c is encoded within the 12S ribosomal RNA region of mitochondrial DNA (mtDNA), highlighting the role of mitochondria as regulators of cellular communication in addition to energy production.
The discovery of MOTS-c significantly expanded scientific understanding of mitochondrial biology. Researchers continue investigating how mitochondrial-derived peptides regulate communication between mitochondria and the nucleus, influence cellular stress responses and contribute to metabolic homeostasis.
Understanding MOTS-c
MOTS-c is synthesised from a short open reading frame located within mitochondrial 12S rRNA. Experimental studies have reported that under conditions of metabolic stress the peptide may translocate to the nucleus, where it participates in the regulation of genes associated with stress adaptation and metabolic homeostasis.
MOTS-c and AMPK signalling
One of the most extensively investigated aspects of MOTS-c biology is its relationship with AMP-activated protein kinase (AMPK), an intracellular energy sensor involved in metabolic regulation. Experimental studies have reported activation of AMPK-associated signalling pathways under laboratory conditions, leading researchers to investigate interactions with energy metabolism pathways, lipid metabolism, mitochondrial function and cellular stress responses.
Why MOTS-c is a focus of research
Research involving MOTS-c has expanded across mitochondrial biology, endocrinology, molecular genetics, exercise physiology, gerontology, metabolism and systems biology. Experimental investigations have examined energy metabolism pathways, peptide receptor signalling, skeletal tissue physiology, mitochondrial biogenesis, oxidative stress, cellular signalling responses, exercise adaptation and ageing models.
MOTS-c and ageing research
Observational studies have reported that endogenous circulating MOTS-c concentrations may decline with advancing age, prompting further investigation into its physiological role during ageing. Most published human studies have been observational, measuring endogenous circulating MOTS-c rather than exogenous peptide.
MOTS-c as a research tool
MOTS-c has also become an important research tool for investigating cellular adaptation to physiological stress. Experimental models suggest that the peptide participates in adaptive responses to metabolic stress, nutrient availability and exercise-related signalling.
Research-grade supply and quality control
At livvmore, MOTS-c is supplied exclusively for laboratory research and scientific investigation. Every batch undergoes quality control procedures designed to verify peptide identity, purity and consistency before release. Batch-specific Certificates of Analysis (COA) are available to support laboratories requiring documented quality assurance.
Current state of the evidence
Researchers should recognise that while MOTS-c has generated substantial scientific interest and accumulated an expanding body of laboratory evidence, the majority of published findings derive from cell culture and animal models. Human interventional evidence remains limited, and well-designed research studies continue to be required.
For laboratory research use only. Not for human or veterinary use.
Documented by batchCatalogued by compound identity
Compound identityCAS · Molecular weight · Sequence
Batch recordsBatch · Lot · Production date
Independent testingHPLC · LC-MS
Specifications
Product specifications
Format
Lyophilized powder
Appearance
White lyophilized powder
Molecular weight
2174.6 g/mol
CAS number
1627580-64-6
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 residues)
Storage
Store refrigerated at 2–8°C, protected from light and moisture. For extended storage, follow your laboratory's standard storage procedures.
Batch documentation
The certificate for the current batch
Every batch is third-party tested. The batch-specific certificate of analysis is available on request; the layout below shows the fields it records.
Certificate of analysis
Specimen layout
- Compound
- product identity
- Batch
- batch number
- Produced
- production date
- Appearance
- recorded appearance
- Identity (HPLC)
- recorded
- Mass (LC-MS)
- recorded
Specimen layout. A batch-specific certificate of analysis is issued for each production run and is available on request.
- Compound and batch identify the exact material supplied.
- Batch and production date tie the certificate to its production run.
- Identity records (HPLC, LC-MS) document what was tested on the batch.
Testing records
What each batch record documents
Every batch is accompanied by laboratory records. The entries below describe what each record documents.
Mass (LC-MS)
Mass spectrometry records the compound’s measured mass to document molecular identity.
Appearance
The physical appearance of the material is recorded, for example a white lyophilized powder.
Batch record
Each batch is logged with a lot number and production date for traceability.
These are records of laboratory testing carried out on the batch. They document compound identity for research use and are not a statement of safety, suitability, or fitness for any use.
Research information
MOTS-c research information
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S ribosomal RNA gene and is recognised as a key mitochondrial signalling peptide involved in cellular stress adaptation and metabolic regulation. Most published evidence originates from cell culture and animal models, while human evidence remains comparatively limited.
Current areas of scientific investigation
- Mitochondrial biology. Research focuses on mitochondrial-derived peptide biology, mitochondrial-to-nuclear communication, retrograde signalling and regulation of cellular energy homeostasis.
- AMPK signalling. Experimental studies continue investigating activation of AMP-activated protein kinase (AMPK) and downstream pathways involved in energy balance.
- Exercise physiology. Laboratory investigations examine mitochondrial adaptation, skeletal tissue metabolism and exercise-induced signalling.
- Metabolic research. Scientists continue investigating energy metabolism pathways, peptide receptor signalling, lipid metabolism and cellular energy regulation.
- Ageing research. Observational studies suggest endogenous MOTS-c concentrations may decline with age, prompting ongoing investigations into mitochondrial ageing.
- Oxidative stress and cellular adaptation. Researchers examine antioxidant responses, oxidative stress pathways and adaptive cellular signalling.
- Molecular pharmacology. Studies investigate peptide stability, intracellular transport, nuclear localisation and regulation of gene expression.
Current evidence landscape
The published literature surrounding MOTS-c has expanded considerably since its discovery. Most mechanistic evidence derives from laboratory and animal studies, while human evidence consists primarily of observational studies and early-stage research investigation. As of 2026, a registered Phase 2a randomized study evaluating MOTS-c is recruiting participants; no activity results have yet been reported.
Scientific limitations
- Most evidence derives from cell culture and animal models.
- Human intervention data remain limited.
- No completed large-scale trials of exogenous MOTS-c have reported results.
- Pharmacokinetic and long-term human safety data remain under investigation.
- Continued translational and scientific research is required.
Selected scientific references
- Lee C, Kim KH, Cohen P. Free Radic Biol Med. 2016.
- Mohtashami Z, et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. International Journal of Molecular Sciences. 2022.
- Review. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and ageing.
For laboratory research use only. Not for human or veterinary use.
Frequently asked questions
Questions and documentation
What is MOTS-C?
MOTS-C is catalogued in the Mitochondrial research peptides collection and supplied as a white lyophilized powder for in-vitro laboratory research. It is listed by CAS number 1627580-64-6 and a molecular weight of 2174.6 g/mol. It is not for human or veterinary use.
What is the CAS number for MOTS-C?
The CAS number recorded for MOTS-C is 1627580-64-6.
What is the molecular weight of MOTS-C?
The molecular weight recorded for MOTS-C is 2174.6 g/mol.
How is MOTS-C supplied and stored?
MOTS-C is supplied as a white lyophilized powder. Store refrigerated at 2–8°C, protected from light and moisture. For extended storage, follow your laboratory's standard storage procedures.
What does research use only mean?
All products are supplied strictly for in-vitro laboratory research and are not for human or veterinary use, diagnosis, treatment, or personal consumption.
How are the products documented?
Every batch is third-party tested and documented. The certificate of analysis is available on request.
Is a certificate of analysis available?
Every batch is third-party tested, and the batch-specific certificate of analysis is available on request.
Who can purchase?
By placing an order, purchasers acknowledge that the product is intended solely for laboratory research use and agree to the Research Use Terms.
Fulfilment
How orders are handled
-
Secure packaging
Sealed, labelled research vials, packed to protect integrity in transit.
-
Third-party tested
Every batch is third-party tested; the certificate of analysis is available on request.
-
Research customers only
Supplied to qualified researchers for laboratory research use.
Shipping options and timelines are shown at checkout.
- Third-party tested Independent testing per batch
- Documented by batch Batch and lot records
- Certificate of analysis Available on request
- Identity by HPLC & LC-MS Compound identity documented
- Secure packaging Sealed, labelled research vials
- Supplied for laboratory research Research use only
Order
MOTS-C
Indicative pricing · checkout opens at launch
Checkout opens at launch, once an approved payment provider is in place.