Identity (HPLC)
High-performance liquid chromatography records the compound’s retention profile against a reference.
Research peptide
KPV
Lyophilized powder, catalogued by compound identity and backed by a certificate of analysis for its production batch.
For laboratory research only. Not for human or veterinary use.
Research use only
99.11% purity · batch B10001
Batch tested
$90.00In stock
Size
10 mg
Buying option
Buy now · $90.00In stock
Sealed, labelled vials · US delivery
| Quantity | 5–9 | 10+ |
|---|---|---|
| Discount | 10% | 15% |
| Price | $81.00 | $76.50 |
Volume pricing.
View specifications Batch documentation Certificate of analysis
- Third-party tested
- Secure packaging
- Supplied for laboratory research
- Identity by HPLC & LC-MS Compound identity documented per batch.
- Batch-specific COA A certificate of analysis per batch.
- Secure packaging Sealed, labelled research vials.
- Tested at USC University of Southern California, every batch.
Documented by batch
Every batch is catalogued, tested and recorded.
Overview
KPV (Lys-Pro-Val) Research Peptide
Premium research-grade KPV for scientific and laboratory research.
KPV (Lys-Pro-Val) is a synthetic tripeptide corresponding to the C-terminal three amino acids of the endogenous melanocortin peptide α-MSH. Although it consists of only three amino acid residues, KPV has attracted considerable scientific interest because experimental studies have reported biological activity independent of the full α-MSH peptide.
Over the past several decades, KPV has become an important investigational compound in laboratory research examining immune signalling, epithelial biology, gastrointestinal physiology, skin biology, innate immune biology and peptide pharmacology.
Understanding KPV
KPV is composed of three naturally occurring amino acids, lysine, proline and valine, and may also be described in the scientific literature as α-MSH(11–13). Modern laboratory-grade KPV is produced using solid-phase peptide synthesis, followed by purification using high-performance liquid chromatography (HPLC) and analytical characterisation by mass spectrometry to confirm identity and purity.
Why KPV is a focus of research
Unlike larger melanocortin peptides that activate melanocortin receptors through the conserved His-Phe-Arg-Trp pharmacophore, KPV lacks this receptor-binding sequence. Nevertheless, laboratory investigations have reported activity within immune signalling pathways across a range of experimental models, prompting continued research into receptor-independent signalling and intracellular pathways.
This observation has made KPV an important research tool for scientists investigating peptide-mediated regulation of immune responses and epithelial homeostasis.
Research applications
The peptide has become particularly important in experimental research involving intestinal epithelial biology. Several investigations have demonstrated transport of KPV through the peptide transporter PepT1, allowing researchers to study epithelial uptake mechanisms, intracellular signalling and immune responses in gastrointestinal cell models. Experimental findings have suggested modulation of NF-κB and MAPK signalling pathways under laboratory conditions, although these observations remain largely confined to cell culture and animal research.
Research involving KPV now spans multiple scientific disciplines including gastroenterology, dermatology, immunology, molecular biology, peptide chemistry, epithelial physiology and microbiology. Published investigations have examined epithelial barrier integrity, cytokine signalling, keratinocyte biology, antimicrobial activity and mucosal immune signalling in controlled laboratory settings.
Quality and supply
At livvmore, KPV is supplied exclusively for laboratory research and scientific investigation. Every batch undergoes quality control procedures designed to verify identity, purity and consistency before release, with batch-specific Certificates of Analysis (COA) available to support research laboratories.
For laboratory research use only. Not for human or veterinary use.
Further reading: KPV: Research Compound Profile · Certificate of analysis library
Documented by batchCatalogued by compound identity
Compound identityCAS · Molecular weight · Sequence
Batch recordsBatch · Lot · Production date
Independent testingHPLC · LC-MS
Specifications
Product specifications
Format
Lyophilized powder
Appearance
White lyophilized powder
Molecular weight
342.43 g/mol
CAS number
67727-97-3
Sequence
Lys-Pro-Val (tripeptide)
Storage
Store refrigerated at 2–8°C, protected from light and moisture. For extended storage, follow your laboratory's standard storage procedures.
Quality & testing
Certificate of analysis
Every batch is third-party tested for identity and analytical purity. Where the certificate for the current batch is published it appears below; otherwise it is available on request.
KPV
Independently analyzed by the USC Alfred E. Mann Multi-Omics Mass Spectrometry Core.
Testing records
What each batch record documents
Every batch is accompanied by laboratory records. The entries below describe what each record documents.
Mass (LC-MS)
Mass spectrometry records the compound’s measured mass to document molecular identity.
Appearance
The physical appearance of the material is recorded, for example a white lyophilized powder.
Batch record
Each batch is logged with a lot number and production date for traceability.
These are records of laboratory testing carried out on the batch. They document compound identity for research use and are not a statement of safety, suitability, or fitness for any use.
Research information
Research context
KPV has become one of the most extensively investigated short peptides within immune signalling biology because of its reported activity in experimental models, despite lacking the classical melanocortin receptor-binding motif. Published research has primarily focused on understanding its molecular transport, intracellular signalling pathways and interactions with epithelial and immune cells under laboratory conditions. The available evidence is derived predominantly from cell culture and animal studies, while published evidence from human studies remains extremely limited.
Current areas of scientific investigation
- Gastrointestinal biology. The largest body of KPV research examines gastrointestinal epithelial biology and intestinal disease models. Laboratory investigations have explored peptide uptake by the PepT1 transporter, epithelial barrier function and immune signalling in intestinal tissues.
- Epithelial barrier research. Researchers have investigated KPV in epithelial models to better understand barrier integrity, epithelial turnover and communication between epithelial cells and immune pathways.
- Immune signalling. Experimental studies have reported modulation of NF-κB and MAPK signalling pathways following KPV exposure in laboratory models. These pathways regulate numerous immune responses and remain an important focus of peptide research.
- Skin biology. Laboratory investigations have explored KPV in keratinocyte cultures and experimental skin models to better understand epithelial biology.
- Immunology. Current investigations continue examining interactions between KPV and innate immune signalling pathways, cytokine regulation and epithelial immune responses.
- Antimicrobial activity. Several laboratory studies have reported antimicrobial activity associated with KPV in experimental systems. Researchers continue investigating these observations in preclinical models.
- Molecular pharmacology. KPV continues serving as a model compound for investigating short-peptide transport, intracellular signalling, peptide stability and structure-function relationships.
Current evidence landscape
The scientific literature surrounding KPV consists predominantly of laboratory and animal investigations. Although these studies provide valuable mechanistic insight, published evidence from human studies remains extremely limited. There are currently no large, completed randomized controlled human trials characterising its activity for any specific application. KPV therefore remains an investigational peptide supplied for laboratory research rather than an approved product.
Scientific limitations
- Predominantly preclinical evidence
- Very limited published human research
- No completed large-scale randomized controlled trials
- Ongoing investigation into molecular mechanisms
- Continued need for pharmacokinetic and formulation studies
- Requirement for independent replication across multiple research centres
Selected scientific references
- Dalmasso G, et al. Gastroenterology. 2008.
- Kannengiesser K, et al. Inflamm Bowel Dis. 2008.
- Peer-reviewed reviews summarising KPV transport, PepT1 uptake and NF-κB/MAPK signalling in preclinical evidence.
- Recent evidence reviews discussing KPV as an α-MSH-derived tripeptide and current evidence limitations.
The information presented summarises findings from the published scientific literature and is provided solely for educational and laboratory research purposes. livvmore supplies KPV exclusively for laboratory research use.
For laboratory research use only. Not for human or veterinary use.
Research profile: KPV: Research Compound Profile
Frequently asked questions
Questions and documentation
What is KPV?
KPV is catalogued in the Peptide fragments collection and supplied as a white lyophilized powder for in-vitro laboratory research. It is listed by CAS number 67727-97-3 and a molecular weight of 342.43 g/mol. It is not for human or veterinary use.
What is the CAS number for KPV?
The CAS number recorded for KPV is 67727-97-3.
What is the molecular weight of KPV?
The molecular weight recorded for KPV is 342.43 g/mol.
How is KPV supplied and stored?
KPV is supplied as a white lyophilized powder. Store refrigerated at 2–8°C, protected from light and moisture. For extended storage, follow your laboratory's standard storage procedures.
What does research use only mean?
All products are supplied strictly for in-vitro laboratory research and are not for human or veterinary use, diagnosis, treatment, or personal consumption.
How are the products documented?
Every production batch is independently identity- and purity-tested at a university laboratory, the USC Alfred E. Mann Multi-Omics Mass Spectrometry Core, with a certificate of analysis documented for each batch. Published results are collected in the COA library.
Is a certificate of analysis available?
A certificate of analysis is documented for each production batch, recording the batch number, identity confirmation, estimated purity, method and test date. Published results are in the COA library; the batch-specific certificate for a given order is available on request.
Who can purchase?
By placing an order, purchasers acknowledge that the product is intended solely for laboratory research use and agree to the Research Use Terms.
Fulfilment
How orders are handled
-
Secure packaging
Sealed, labelled research vials, packed to protect integrity in transit.
-
Third-party tested
Every batch is third-party tested; the certificate of analysis is available on request.
-
Research customers only
Supplied to qualified researchers for laboratory research use.
Shipping options and timelines are shown at checkout.
- Third-party tested Independent testing per batch
- Documented by batch Batch and lot records
- Certificate of analysis Available on request
- Identity by HPLC & LC-MS Compound identity documented
- Secure packaging Sealed, labelled research vials
- Supplied for laboratory research Research use only
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KPV
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